Ontogeny of L-Glutamic Acid Decarboxylase and γ-Aminobutyric Acid Concentration in Human Kidney

Accumulation of γ-aminobutyric acid and transcription of glutamate decarboxylase in Brassica juncea (L.) Czern

Mustard leaf (Brassica juncea (L.) Czern.) using as material of a traditional fermented vegetable food (Kimchi) in Korea, is one of the important vegetables. Two cultivars of mustard (red and green) were grown in the experimental farm of Chungnam National University and allowed them to grow until flowering stage. In this study, the variability of γ-aminobutyric acid (GABA) content and mRNA tran...

cloning of glutamate decarboxylase and production of γ-aminobutyric acid from lactobacillus brevis

Glutamic acid decarboxylase in Rhodotorula glutinis.

1. The metabolism of 131I-labelled thyroglobulin from four mammalian species has been studied. 2. The rat, dog and monkey rapidly metabolize the homologous protein, with the formation of iodide, iodotyrosines and thyroxine. Rabbit thyroglobulin disappears slowly from the plasma of the rabbit after intravenous injection, and no metabolites have so far been detected in the blood. 3. The developme...

Cleft palate and decreased brain gamma-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase.

In addition to its role as an inhibitory neurotransmitter, gamma-aminobutyric acid (GABA) is presumed to be involved in the development and plasticity of the nervous system. GABA is synthesized by glutamic acid decarboxylase (GAD), but the respective roles of its two isoforms (GAD65 and 67) have not been determined. The selective elimination of each GAD isoform by gene targeting is expected to ...

Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67.

The functions of neurotransmitters in fetal development are poorly understood. Genetic observations have suggested a role for the inhibitory amino acid neurotransmitter gamma-aminobutyric acid (GABA) in the normal development of the mouse palate. Mice homozygous for mutations in the beta-3 GABAA receptor subunit develop a cleft secondary palate. GABA, the ligand for this receptor, is synthesize...